Concomitant Use of Lisinopril Reduces the Effect of Aspirin on Bleeding

Objective: To determine the Lisinopril and Aspirin interaction through their concurrent effect on bleeding in adult male rabbits. Methods: Twenty four healthy adult male rabbits were used. Bleeding time of each animal was determined by Duke’s Method. They were divided randomly in three groups containing equal number of animals into Control, Aspirin, Lisinopril and Combination groups. After oral administration of the drug(s), the bleeding time of the animals was again determined by same method. Results: Prolongation of bleeding time was significant (p<0.05) in Aspirin and combination groups but insignificant (p>0.05) in Lisinopril group after 1 hour. It was significant (p<0.05) in Aspirin and Lisinopril groups but insignificant (p>0.05) in Combination group after 24 hours. This change was observed after 48 hours too. Conclusion: Concurrent use of Lisinopril reduces the effect of Aspirin on Bleeding after a certain time period.